Widely consumed vegetable oil leads to unhealthy gut: Study
The study states that excessive consumption of soyabean oil leads to obesity, diabetes, autism, Alzheimer’s disease, anxiety, and depression.
High use of soybean oil has been associated with obesity and diabetes, as well as autism, Alzheimer’s disease, anxiety, and depression. Add ulcerative colitis, a kind of inflammatory bowel disease (IBD) characterised by chronic inflammation of the large intestine, to the growing list.
Researchers at the University of California, Riverside, examined the gut of mice that were consistently fed a diet high in soybean oil for up to 24 weeks in the lab. They found beneficial bacteria decreased and harmful bacteria (specifically, adherent invasive Escherichia coli) increased — conditions that can lead to colitis.
Soybean oil is the most commonly used edible oil in the United States and is increasingly being used in other countries, particularly Brazil, China, and India. In the U.S., soybean production took off in the 1970s for use as animal feed; a byproduct of the increasing trend in growth was soybean oil. Soybeans, a good source of protein, are easy and cheap to grow.
Our work challenges the decades-old thinking that many chronic diseases stem from the consumption of excess saturated fats from animal products, and that, conversely, unsaturated fats from plants are necessarily more healthful,” said Poonamjot Deol, an assistant professional researcher in the Department of Microbiology and Plant Pathology and a co-corresponding author on the paper published July 3 in Gut Microbes, an open access journal.
Deol explained it is linoleic acid in soybean oil that is the main concern.
“While our bodies need 1-2% of linoleic acid daily, based on the paleodiet, Americans today are getting 8-10% of their energy from linoleic acid daily, most of it from soybean oil,” she said. “Excessive linoleic acid negatively affects the gut microbiome.”
Deol and her co-authors found that a diet high in soybean oil encourages the growth of adherent invasive E. coli in the gut. This bacterium uses linoleic acid as a source of carbon to meet its nutritional demands. Further, several beneficial bacteria in the gut are not able to withstand linoleic acid and die off, which results in harmful bacteria growing out. Adherent invasive E. coli has been identified in humans to cause IBD.
“It’s the combination of good bacteria dying off and harmful bacteria growing out that makes the gut more susceptible to inflammation and its downstream effects,” Deol said. “Further, linoleic acid causes the intestinal epithelial barrier to become porous.”
The barrier function of the intestinal epithelium is critical for maintaining a healthy gut; when disrupted, it can lead to increased permeability or leakiness. Toxins can then leak out of the gut and enter the bloodstream, greatly increasing the risk of infections and chronic inflammatory conditions, such as colitis. The researchers note that the increase in IBD parallels the increase in soybean oil consumption in the U.S. and hypothesize the two may be linked.
Toxicologist Frances M. Sladek, a professor of cell biology and a co-corresponding author on the research paper, recalled that heart disease was linked to saturated fats in the late 1950s.
“Since studies showed that saturated fats can be unhealthy, it was assumed that all unsaturated fats are healthy,” she said. “But there are different types of unsaturated fats, some of which are healthful. For example, the unsaturated fat fish oil is well known to have many beneficial health effects. People therefore assumed that soybean oil is perfectly safe and healthier to consume than other types of oils, without actually doing a direct comparison as we have done.”
Sladek noted that linoleic acid is an essential fatty acid. The soybean oil the researchers used in their experiments had 19% linoleic acid. The American Heart Association recommends 5 to 10% of daily calories be from omega-6 polyunsaturated fatty acids, such as linoleic acid, in order for the heart to remain healthy. Many seed oils – safflower and sunflower, for example — are sources of linoleic acid. Animal fat can also be a source.
“Every animal has to get linoleic acid from the diet,” Sladek said. “No animal can make it. A small amount of it is needed by the body. But just because something is needed does not mean a lot of it is good for you. Several membranes in the body, in the brain, for example, require linoleic acid for the cells to function properly. If all we ate was saturated fats, our cell membranes would become too rigid and not function properly. Future studies are needed to determine the tipping point for how much daily linoleic acid consumption is safe.”
According to Sladek and Deol, olive oil, which has lower amounts of linoleic acid, is a healthier oil to consume.
“Olive oil, the basis of the Mediterranean diet, is considered to be very healthy; it produces less obesity and we have now found that, unlike soybean oil, it does not increase the susceptibility of mice to colitis,” Sladek said.
James Borneman, a professor of microbiology and plant pathology at UCR and a co-corresponding author on the paper, is an expert on the gut microbiome. He has collaborated at UCR with several groups on research projects, including studies investigating how gut microbes prevent obese people from losing weight. For the current study, he teamed up with Deol and Sladek to examine the gut microbes of the mice that were fed a high soybean oil diet.
“Adherent invasive E. coli contributes to IBD in humans, and the fact that we find this E. coli in these mice is concerning,” he said. “Sometimes, it can be unclear how research done in mice translates to humans, but in this study it is fairly clear.”
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